IGF-1/GFP (Somatomedin C, IGF-I, MGF, Insulin-Like Growth Factor 1)

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Introduction

IGF1 human recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain fused to both GST and GFP tags.

Description

IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure. Its primary action is mediated by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), which is present on many cell types in many tissues.

Application

Immunofluorescence, FACS, ELISA, Western blot, protein-protein interactions, Pull-down assay,

Purification method

Affinity chromatography.

Formulation

PBS solution 0,5 mg/ml, 30% glycerol, contains 10 mM glutation.

Specificity

Binds to IGF-1 receptor.

Storage

-80°C